CBD & Liver Diseases – A great potential for Treatments

CBD & Liver Diseases – A great potential for Treatments

cbd & liver

Recent studies discovered that CBD or cannabidiol, a non-psychoactive compound extracted from cannabis, can improve the treatments for a variety of illnesses and make them more efficient. The same happened in the case of liver diseases, number studies being conducted to understand better how CBD acts when the liver is damaged and in what ways this compound can be used to improve the life quality in the case of patients that suffer from various liver conditions.

The Endocannabinoid System & the Liver

It is known that the human body has a number of cannabinoid receptors, CB(1) and CB(2), which form the endogenous cannabinoids system. These receptors bind to the CBD molecules and create a set of reactions that are beneficial for our body’s processes, although how this happens is not fully understood by researchers.

When it comes to CBD and liver diseases, researchers discovered that the EC system, mentioned earlier, is not active when the liver is healthy. But, once a chronic liver disease gets installed, the EC system is “turned on”, being part of the pathogenesis of a series of liver conditions, such as non-alcoholic fatty liver disease, fibrosis progressing to cirrhosis, and appearance of cardiovascular abnormalities developed by the presence of cirrhosis.

Also, in case of acute injury of the liver, EC is responsible for some of the inflammatory responses and influences the mechanisms that manage cell damage; this is why it is considered to have great potential when it comes to treating liver diseases.

Related Articles:

Cannbinoid Receptors (CB1) and the liver

cb 1 receptors cbdThe CB(1) agonists are currently considered the best available option in the treatment of non-alcoholic fatty liver and even of cirrhosis, the patients that utilized this pharmaceutical tool showed improvements in their condition, the development of fibrosis being slowed down, while the cardiovascular alterations associated with an advanced stage of the illness were attenuated.

Also, CBD can be the answer doctors are looking when the aim is to protect the liver against injuries.

The signaling of the inflammatory process and the liver’s responses in cases of hepatic ischemia or reperfusion injury are significantly reduced by cannabidiol, which prevents the oxidative stress and death of liver cells. In case of liver surgery or liver transplant, the biggest challenge is to prevent the liver from being damaged.

Laboratory studies on mice determined that CBD can be a highly efficient new strategy of managing the inflammation and tissue injury of the liver, working independently of cannabinoid receptors CB1 and CB2, which makes the discovery even more important.

Related Articles:

CBD & liver fibrosis

If we are to take a look at a fibrotic liver, the condition appears when the hepatic stellate cells are activated, which multiply excessively and produce collagen in excess quantities, leading to liver fibrosis. CBD was proved to produce the death of these activated hepatic stellate cells, which can turn into an effective treatment for liver fibrosis.

In another study involving mice that suffered from hepatic encephalopathy, the use of CBD shows that a better treatment can be indeed developed. Hepatic encephalopathy appears when an acute or chronic liver failure occurs, leading to this neuropsychiatric disorder.

The mice treated with CBD for this particular disease showed improvement in their liver functions, as cannabidiol restored the plasma levels of ammonia, liver enzymes, and bilirubin. At the same time, the administration of CBD helped to normalize the brain function of the same mice as well, which is considered to be possible due to the double action of CBD, both on the brain and liver at the same time.

CBD & Liver Cirrhosis

Cirrhosis, a liver disease that is affecting so many people, also has high chances to be treated by CBD in the near future. Of course, many still have to be discovered and understood when it comes to the action of CBD on the liver and human organism, as it is a complex process that has been unrolled in in-vitro studies and on laboratory mice and rats.

But, the results that have been obtained this way are more than promising, so clinical trials of CBD treatments for liver conditions may soon follow to attest the validity of CBD treatment. In previous studies, the cannabinoid receptor CB1 was proven to have a positive impact on the management of liver fibrosis, non-alcoholic cirrhosis, and a number of other conditions that affect the liver.

The Importance of activation of the CB2 Receptors in the case of a Liver disease

But switching off or blocking the CB1 receptor could slow down the process of liver disease. This is one of the reasons why CBD as a cannabinoid is so promising as a therapeutic agent in liver diseases. It acts as an antagonist to THC and can block the activation of the CB1 receptor.

However, CB2 receptor activation has shown beneficial effects on alcoholic fatty liver, hepatic inflammation, liver injury, regeneration and fibrosis and CBD has that potential. Therefore, research suggests that using Cannabinoids to selectively activate the CB2 receptor offers therapeutic potential for cirrhosis and other liver diseases

But, there are studies to show that cannabinoid receptor CB2 can be as useful and efficient when it comes to liver diseases, showing positive results in the case of alcoholic fatty liver, liver injury, fibrosis, and hepatic inflammation. Thus, using cannabis extracts that will particularly activate the CB2 receptor may indeed help in the treatment of these conditions.

Related Articles:

endocannabinoid-system CB1 CB2
Studies on CBD & Liver diseases

In the studies of mice suffering from liver failure, CBD helped by restoring their liver function more efficiently than traditional treatments. In the case of CBD administration, the liver is also protected against ischemia reperfusion, which is one of the most important mechanisms that damage a liver affected by cirrhosis, reducing tissue injury through oxidative and nitrative processes and minimizing the inflammatory pathways.

It is worth noting that these protective actions occur independently on the impact CBD has on the CB2 receptors of the body, which makes them even more efficient and important. When it comes to liver damage caused by alcohol consumption, CBD can protect the liver for being damaged, even more, reducing the autophagy and oxidative stress triggered by alcohol intake. But, the use of CBD in managing cirrhosis goes further than just protecting the liver and aiding in getting its functions restored.

It can also improve the condition of the patient by reducing the presence of symptoms associated with cirrhosis, such as nausea and vomiting, regardless of their causes. At the same time, it improves appetite and leads to the stabilization of the patient’s body weight.

Conclusion

So, CBD has a bright future when it comes to finding a more effective treatment for a variety of liver diseases. The numerous studies made to better understand the action of CBD in the case of liver damage and failure proved that the liver’s functions can be restored, totally or partially, repairing other damages that are produced by severe liver illnesses, such neuropsychiatric disorders, and minimizing the presence of unwanted symptoms. Patients that suffer from various liver diseases could have a chance to live a normal life if CBD will be considered a viable treatment.

Sources:

Featured Products

CBD and Hepatitis C – New researches give hope

CBD and Hepatitis C – New researches give hope

cbd and hepatitis cDid you ever manage to see a connection between CBD or cannabidiol and hepatitis C? Probably not, just as many of us who never imagined that such a connection is possible. In recent years, CBD is constantly surprising both the scientific and medical world, proving its efficiency as a treatment for a large variety of illnesses, in laboratories and clinical trials as well.

But even before there was any scientific evidence, those that used CBD products with the purpose of alleviating the symptoms of their illnesses stated that this compound extracted from the notorious cannabis works. They managed to set themselves free of traditional treatments, traditional meds, which usually come along with a set of unwanted and uncomfortable side-effects, especially in the case of long-term treatments.

New Studies on CBD and Hepatitis C

A new study concerning the therapeutic effects of CBD may bring the much-needed beam of hope in the case of patients that suffer from hepatitis C. But, even so, several years may pass until an actual cure for the HCV virus, which is the one responsible for hepatitis C, will be developed. Still, this is good news and we can only hope that the cure will be available as soon as possible, giving so many patients out there the chance to enjoy a normal life.

Even if the HCV virus affects so many people, there isn’t any vaccine that could prevent the disease from developing. It is worth knowing that HCV is transmitted through infected blood in the majority of cases, like sharing the same injections for the administration of drugs, which is common in underdeveloped communities, or if the medical equipment in hospitals is not properly sterilized. But, it can also be transmitted through unprotected sexual intercourse.

Unfortunately, this virus affects the functionality of the liver, leading to liver failure, liver cancer, and cirrhosis. According to the World Health Organization, approximately 140 million people around the world have the HCV virus as a chronic condition and because of this virus and the disease triggered by it, called hepatitis C, about 700,000 lose their lives every year.

Related Articles:

HCV is widely spread – mainly in third world countries

hepatitis_c_spreadThus, considering these numbers, an effective treatment is more than needed, so that all of these people have a second chance to live. What can one do in present days if he or she receives the diagnosis of being infected with the HCV virus? Counseling and education about the virus and its actions are recommended in all the cases.

Also, one can deal with the infection by attending group therapy and by closely monitoring the liver, with the help of periodic medical checks, but apart from this, there’s not much one can do. Of course, there is always the option of getting antiviral medication, but this kind of treatment is not accessible to everybody and can treat the condition  in all of the cases.

The discovery that CBD could help a patient with hepatitis C is great news for the medical world, which knows that the current treatment for this particular illness is hardly affordable by the patients that live in developing countries, due to the fact that the costs of a single session of treatment can reach $85,000. Thus, it is mandatory for affordable treatments to emerge on the market, so that even those with a precarious financial status could have the chance to enjoy the treatment.

But even if CBD is eventually transformed into a more accessible treatment, there are still many issues to cover when it comes to making it reach patients in the developing countries, such as countries in Central Asia and East Europe, where sharing syringes for drug administration is a rather common practice.

Having in mind that in America, the price of CBD oil can range anywhere between a couple of dollars and a few thousands of dollars, depending on the quality, provenience, and concentration of the oil, as well as the condition for which it is used, it is obvious that there will be serious issues for administering this treatment as well.

Related Articles:

The discovery of an effective medicine is not the only hurdle

life cycle of hcvBut, the first step that has to be made in order to turn CBD oil into hepatitis C treatment is for it to be approved by the World Health Assembly. This assembly has 192 members, each representing a particular country, and all of these members should agree when it comes to making CBD available throughout the world for the treatment of the HCV virus.

Even if CBD would be approved by the World Health Assembly, there is always the major issue of transporting the treatment. In third world countries, the drugs almost never reach their intended destinations, as the transport “leaks”. This means that the drugs are stolen on the way to the hospitals that should receive them, making the treatment impossible to administer to the people that need it.

Let us take the ideal case in which the treatment, CBD oil, in this case, reaches its destination, a hospital or doctor’s office in one of these developing countries. You may think that this is good news, but it is not. The hospitals and other medical units in developing countries lack properly educated medical staff and may utilize medical equipment that is not sterile, so there is always the risk for the patients not to receive the treatment they need.

Unfortunately, the medical services in these countries are far from being efficient and the medical staff that works in hospitals and clinics lack the attention needed when practicing such jobs. Doctors and the medical staff don’t spend a sufficient number of hours in hospitals and clinics, and even when they are present, they see a small number of patients.

Related Articles:

What do the studies say about CBD and hepatitis C?

cannabinoids cbd health propertiesThe recent surge in interest in Medical Cannabis has led to interest in evaluating and validating the therapeutic potentials of Cannabis and its metabolites against various diseases including viruses. Preliminary screening of cannabidiol (CBD) revealed that CBD is active against HCV but not against HBV in vitro. CBD inhibited HCV replication by 86.4% at a single concentration of 10 μM with EC50of 3.163 μM in a dose-response assay. These findings suggest that CBD could be further developed and used therapeutically against HCV.

The direct antiviral activity of CBD against the HCV indicates that the molecule has an effect against both the viral and nonviral hepatitis, otherwise known as autoimmune hepatitis. Autoimmune hepatitis is an inflammatory liver condition elicited by activated T-cells and macrophages.

Studies have shown that CBD by interacting with the CB2 receptor induces apoptosis in thymocytes and splenocytes inhibiting the proliferation of T-cells and macrophages which are responsible for either attacking liver cells or inducing the release of pro-inflammatory cytokines that cause autoimmune hepatitis in the liver.

This are actually pretty amazing results that shows that cbd inhibits the replication of HCV by 86,4%.

Sources:

So yes, there are a view challenges concerning the application of CBD in the treatment of hepatitis C. But, we cannot ignore the fact that the in vitro study performed on CBD and its effects in treating the HCV virus has provided positive results. These results were both recognized by the scientific world and the media because the study represents the first step forward toward finding the first treatment for hepatitis C.

Featured Products

CBD and Parkinson’s Disease – Relief for Symptoms?

CBD and Parkinson’s Disease – Relief for Symptoms?

CBD Parkinson’s

Parkinson’s disease is a cruel condition that affects the brain irremediably. It is a degenerative disease that destroys neurons slow but progressively. Because the affected brain area is closely connected to movement control, people suffering from Parkinson’s have tremors, an unstable posture, and gestures that are rigid, jerky, and uncontrollable. The disease usually appears between 50 to 70 years old, the average age being 57 years old, so it is an illness related to advancement in age. In this article, we take a closer look on CBD & Parkinson’s Disease.

At the debut of this illness, the symptoms can be mistaken for signs of aging, but as it progresses, the diagnostic becomes clearer. While there is no cure for Parkinson’s disease, it was recently discovered that CBD or cannabidiol may help in managing the symptoms better, improving the life quality of a Parkinson’s patient. Parkinson’s disease affects people in their senior years around the world, being the second most commonly met neurological illness, after Alzheimer’s.

The sad part is that one doesn’t have to be too old to develop Parkinson’s, the vast majority of patients being just over 50 years old. Also, men are more likely to be affected by it than women, all patients risking to become the prisoners of their own bodies, not being able to take care of themselves and, thus, suffering from poor life quality.

Thus, it is imperative to find a treatment that can improve the condition of people affected by this illness. And when the answer comes from nature, it is even better. Usually, treatments for severe neurological issues almost always have a range of serious side-effects, but the use of CBD to make Parkinson’s more manageable is looking more than promising.

The role of Dopamine in Parkinson’s disease

cbd dopamineOne of the most severe consequences of Parkinson’s is the loss of the body’s motor functions.

This happens after 60 to 80% of the neurons that produce dopamine are destroyed by the illness.

Dopamine is an essential neurotransmitter in the human brain, responsible for transmitting information among neurons and helping with the regulation of various functions, such as movement and emotional responses.

It also acts in helping us identify reward and making action plans to get those rewards. So, it is easy to see what insufficient levels of dopamine seriously affect one’s life quality. As the neurons producing dopamine cease to exist, Parkinson’s patients start having symptoms like muscle stiffness and rigidity, tremors in the arms, legs, hands, or jaw, decreasing the speed of movement, impaired balance, and coordination issues.

Unfortunately, these aren’t the only symptoms produced by low dopamine levels. Patients will slowly lose their facial expressions, will face confusion and even dementia, will experience fatigue and sleep disturbances, depression, anxiety, fear, and cognitive changes.

Related Article:

The right Diet plays an essential role

The right diet plays an essential roleIt was discovered that digestive imbalance can increase the risk of developing Parkinson’s disease and, in case the illness is already installed, it increases the severity of the symptoms. This happens because certain microbes release toxins in the guts, which leads to the damage of mitochondria, the power plants of every cell in the human body, except the red blood cells.

Without mitochondria to provide energy to cells and to help them repair, cells are dying at a faster pace, increasing the severity of the illness in a shorter period. So, if there is a close connection between intestinal bacteria and Parkinson’s, the evolution of the disease can be manipulated from this point.

A diet rich in fermented foods and supplements containing probiotics will keep mitochondria healthy by creating a proper environment in the gut, also helping with constipation and anxiety, which frequently occur in Parkinson’s patients.

CBD and Parkinson – Cannabis as a treatment?

cannabis parkinsonHere is where cannabis enters the scene, or more precisely one of its compounds, CBD. Researchers discovered that CBD behaves as an “inverse agonist” when it encounters a protein receptor named GPR6, depleting it and stimulating the production of the much-needed dopamine. Thus, with the help of cannabis products, Parkinson’s disease could be slowed down and its symptoms will be easier to bear.

Even though it is hard to believe, cannabis is mentioned as a potential alternative treatment for Parkinson’s since 1888, when it appeared in the scientific paper of Sir William Gowers, a renowned neurologist. Dr. Gower noted that orally ingested Indian hemp by a Parkinson’s patient will have a benefic effect on tremors, reducing their intensity. After just one year of using this hemp, the tremors of the patient, in this case, ceased almost completely.

Newer and modern research offer backup to the theory that cannabis could be successfully used in the case of people suffering from Parkinson’s. It helps with reducing the inflammation caused by the illness and alleviates its symptoms, while also slowing down the progression of the disease in a significant manner.

The fact that CBD is a potent antioxidant and has neuroprotective properties is precisely why this compound found in cannabis can turn out to be so valuable in treating patients that develop severe neurologic conditions, as some preclinical trial proved.

Related Article:

The studies on CBD & Parkinson

Cbd-hemp-oil concentrationAt the moment, studies concerning the use and effects of CBD on Parkinson’s disease are very limited, due to legal prohibition concerning cannabis.

And, in some cases, provide conflicting results they still provide valuable insights of how CBD could help.

What preclinical studies showed sufficient evidence that CBD might work, setting a path for further studies and research, in order to obtain more evidence concerning this potential treatment.

These in-depth studies may even find out whether CBD is enough or it works better in combination with other cannabinoids, according to the different evolutionary stages of the disease.

CBDa – Cannabidiol Acid & Dosage at Parkinson’s.

The cannabidiol acids, present in whole cannabis products, appear to produce the most desired results, although more research is needed in this sector. The studies that have been made so far showed that CBDA, raw cannabinoid acids, which means that they have not been subjected to heating processes that turn them into neutral cannabinoid compounds, have properties such as anti-inflammatory, anti-cancer, anti-nausea, and anti-seizures.

Back in 2004, a survey took place at the Prague Movement Disorder Center, concerning the use of cannabis among the people that were hospitalized there with various health conditions connected to their motor functions. Of all the patients using cannabis during this survey, 45% reported improvements in their motor functions affected by Parkinson’s.

CBDA

Still, it was found that the dosage concerning medical cannabis in the case of Parkinson’s patients can be a bit challenging. It is impossible to set a certain dosage that should be applied to all patients, as it happens in the case of so many drugs because each person’s organism is different and may require a different dosage to enjoy the benefits of cannabis.

Not just the dosage differs from one patient to another, but also the method through which CBD ends up in the patient’s body. Some Parkinson’s patients found more relief by inhaling cannabis products, while others felt better after taking cannabis products rich in CBD sublingually.

Also, some patients feel improvements when using a combination of CBD with THC, so each patient should be treated individually. A person can start with a low dosage, which will be adjusted in time, especially when it comes to using THC products, to see which method, dosage, and combination works best.

Related Article:

CBD & THC – CBD Oil & smoking Marijuana

Juan Sanchez-Ramos M.D. and Ph.D., who is also the Medical Director for the Parkinson Research Foundation, stated that he encourages his Parkinson’s patients to start treatment with a 1:1 CBD: THC ratio if they can find it. Using his book, written in collaboration with Briony Catlow, Ph.D., another doctor, Ethan Russo, created a summary of dosages that provided results in a variety of studies.

Thus, 300 mg of CBD per day improved the quality of life in a significant manner but did not produce any changes on the Unified Parkinson Disease Rating Scale. Tremors, sleep, and slowness of movement were all improved by 0.5 g of smoked cannabis.

Psychotic symptoms decreased with the help of 150 mg of CBD oil that slowly increased in dosage over the span of four weeks. Also, the REM-behavior sleep disorder was positively impacted by the usage of 75 to 300 mg of oral CBD.

CBD & THC

The truth is that even the scarce results of these studies are giving people suffering from Parkinson’s and their families hope. A treatment that is finally providing positive results without having devastating side-effects is indeed remarkable. When it comes to a disease that damages neurons at such a degree that the patient will end up not being able to move at all, to think right, and to make decisions, any small improvement is welcome.

Let us not forget that CBD has natural sources, coming from a plant, which means that it will be better tolerated by the body. In a study involving 22 Parkinson’s patients that started smoking cannabis, reports showed that the patients enjoyed improved motor functions. Their tremors reduced, the rigidity in their muscles loosened, and it was not that difficult anymore to perform various movements that were voluntary.

Related Article:

CBD & Parkinson – The studies have only begun

Still, the current studies only scratch the surface of the real potential behind CBD treatment for Parkinson’s disease. At the moment, there are insufficient studies and tests on this matter, although the results that were discovered so far show a promising future for this treatment.

Besides helping with the improvement of motor impairments, CBD also helps with diminishing anxiety, depression, and pain, which are associated with the disease and affect even more the life quality of a patient.

It is rather intriguing that the description of the illness’s symptoms does not include pain because according to Dr. Blair Ford, pain and physical discomfort are among the first signs that indicate toward a Parkinson’s diagnostic in approximately 85% of the cases.

CBD Oil Industry

Pain is generated by the fact that the body’s tissue is damaged by tremors, inflammation, and rigidity. It is well known the fact that cannabis reduces the sensation of pain, being a treatment that was used thousands of years ago for such purposes.

According to Dr. Mark Rabe, anxiety and depression are both quite frequent in the case of patients suffering from Parkinson’s. About 40% of the patients end up developing anxiety issues due to the illness, while 60% of them become depressed, ranging in intensity from a mild depression to severe and chronic conditions.

And it’s not the grim outcome provided by having Parkinson’s that trigger depression, as it is believed that the chemical changes that take place inside the brain, due to the disease, are responsible for producing these changes.

CBD has been used for a while to reduce depression and improve the mental stability of many people, regardless of the underlying cause. It works well in the case of anxiety as well, reducing discomfort and cognitive impairment. Also, used in the early stages of the disease, cannabis products can protect neurons from being damaged further more.

Related Article:

Summary – CBD & Parkinson’s Disease

While CBD does not provide a final cure for Parkinson’s, it can bring a significant improvement in the fight against the illness’s terrible symptoms. This is why more studies need to be unrolled in this direction, because everybody suffering from a disease, especially one that affects the brain, would like to have a chance to lead a decent life and not become entirely dependent on another person for care and everyday tasks.

CBD could redeem dignity and self-esteem for people suffering from Parkinson’s, also improving their morale by treating depression, stress, and anxiety. It also allows people to sleep better and be more active, by reducing pain and improving mobility. All these reasons should be good enough in order for more studies to take place in this particular sector.

Until an actual cure is found, a treatment that improves life quality will be more than welcome. CBD is entirely safe to be used for medical purposes because it does not have a psychoactive effect. In fact, it helps diminish psychotic episodes, promoting relaxation and a calmer state of mind.

While it may take a while for researchers to fully understand how CBD works in protecting our brain, the positive results speak for themselves and such treatment should be made available as soon as possible.

Sources
  • Abrams, D. (2010, Winter). Cannabis in Pain and Palliative Care. The Pain Practitioner, pp. 35-45.
  • AC Howlett, F. B. (2002). International Union of Pharmacology. XXVII. Classification of cannabionid receptros. Pharmacological Reviews, 161-202.
  • Aidan J. Hampson, J. A. (2003). USA Patent No. 6,630,507.
  • Barbara A. Pickut, W. V. (2013). Mindfulness based intervention in Parkinson’s disease leads to structural brain changes on MRI A randomized longitudinal study. Clinical Neurology and Neurosurgery, 2419-2425.
  • Birony Catlow, J. S.-R. (2015). Cannabinoids for the Treatment of Movement Disorders. Current Treatment Options in Neurology.
  • C Garcia, C. P.-G.-A.-R. (2011). Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9THCV in animal models of Parkinson’s disease. British Journal of Pharmacology, 1495-1506.
  • Chagas MH, Z. A.-P. (2014). Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial. Journal of Phsychopharmacology, 1088-98.
  • David N. Hauser, T. G. (2013). Mitochondrial dysfunction and oxidative stress in Parkinson’s disease and monogenic parkinsonism. Neurobiology of Disease, 35-42.
  • David Perlmutter, M. (2015). Belly and Brain on Fire. In M. David Perlmutter, Brain Maker (pp. 49-70). New York: Little, Brown and Company.
  • Foundation, N. P. (2017, June 19). What is Parkinson’s. Retrieved from National Parkinson’s Foundation:http://www.parkinson.org/understanding-parkinsons/what-is-parkinsons
  • Foundation, P. D. (2017, 6 21). Parkinson’s Statistics. Retrieved from Parkinson’s Disease Foundation :http://www.pdf.org/parkinson_statistics
  • Goldstein, B. (2016). Parkinson’s Diseas. In B. Goldstein, Cannabis Revealed (pp. 206-208). Bonni Goldstein.
  • L. Klingelhoefer, H. R. (2017). Hypothesis of Ascension in Idiopathic Parkinson’s Disease. Neurology Intereatnional,E28-35.
  • Leonard L. Sokol, M. J. (2016). Letter to the Editor: Cautionary optimism: caffeine and Parkinson’s disease risk. Journal of Clinical Movement Disorders, pp. 3-7.
  • Lisa Klingelhoefer, H. R. (2015). Pahtogenesis of Parkinson disease—the gut-brain axis and environmental factors. Nature, 625-636.
  • Lotan I, T. T. (2014). Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease:. Clin Neuropharmacol, 37(2)-41-4.
  • Madeleine E. Hackney1 and Gammon M. Earhart1, 2. (2008). Tai Chi Improves Balance and Mobility in People with Parkinson Disease. Gait and Posture, 456-460.
  • National Institute of Health. (2017). NIH Human Microbiome Project HOME Page. Retrieved from NIH Human Microbiome Project: http://hmpdacc.org
  • Pal Pacher, S. B. (2006). The Endocannabinoid System as an Emerging Target. Pharmacological Reviews, 389-462.
  • Parker, R. M. (2013). The Endocannabinoid System and the Brain. The annual Review of Psychology, 21-47.
  • Paula Perez-Pardo, T. K. (2017). The gut-brain axis in Parkinson’s disease: Possibilities for food -based therapies. European Journal of Pharmacology, http://www.sciencedirect.com/science/article/pii/S0014299917303734.
  • Perlmutter, D. (2015). Brain Maker. New York: Little, Brown and Company.
  • Russo, E. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 1344-64.
  • Russo, E. B. (2015). Current status and future of cannabis research. Clinical Researcher, 58-63.
  • Russo, E. B. (2015, January). Introduction to the Endocannabinoid system. Retrieved from Phytecs.com:http://www.phytecs.com/wp-content/uploads/2015/02/Russo-Introduction-to-…
  • Russo, E. B. (2016). The Medical Use of Cannabis and Cannabinoids in Parkinson’s Disease. Retrieved from The Answer Page: https://www.theanswerpage.com/
  • Schecter, G. L. (2010). The Endocannabniond system. In J. Holland, The Pot Book (pp. 52-62). Rochester, Vermont: Park Street Press.
  • Venderová K, R. E. (2004). Survey on cannabis use in Parkinson’s disease: subjective improvement of motor symptoms. Movement Disorder, 1102-6.
  • Yevonne Searls Carlgrove, N. S. (2012). Effect of Yoga on Motor Function in People with parkinosn’s Disease: A Randomized Controled Piolot Study. Yoga and Physical Therapy.
  • Yudowski, D. A. (2017). Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. Frontiers in Cellular Nueroscience, article 294.
  • Zuardi AWC. J. (2009). Cannabidiol for the treatment of psychosis in Parkinson’s disease. Journal of Phsychopharmacology, 979-83.
Featured Products

CBD Oil and Autism – More Studies on Cannabidiol

CBD Oil and Autism – More Studies on Cannabidiol

CBD Oil and AutismAutism is a very complex disorder, more precisely a spectrum of disorders because it includes a variety of disorders that affect the development of the brain at the same time. While autism affects each patient individually, almost all patients have a few symptoms in common. These are difficulties in communication, difficulties in interacting with other people, and the development of repetitive behaviors, sometimes these behaviors being negative and self-injurious. In this article, we deal with CBD Oil and Autism. Read more

CBD for Insomnia – Cannabidiol & Sleep Disorders

CBD for Insomnia – Cannabidiol & Sleep Disorders

cbd for insomniaAre you experiencing a difficulty falling asleep at night? If you are reading this, and if your answer to this question is “yes”, then you have stumbled onto the right website. Read on to find out how CBD could be the solution to your problem with insomnia.

First of all, let’s find out what CBD actually is. Are there any experts and generally knowledgeable people among us? Then please bear with me while I explain to the newbies that have no knowledge about CBD, what this substance is:

CBD is the short term for Cannabidiol, which is one of about 80 Cannabinoids found in Cannabis.

Yes, that Cannabis, which is commonly known as Marijuana among the greater percentage of the world’s population, and which is more than often still considered to be synonymous with illegal drugs, narcotics, psychoactive substances, etc. (whichever term you prefer to use when talking about substances that can make you “high”). But indiscriminately perceiving Cannabis as a “damaging drug” is presumptuous, to say the least.

Related Articles:

CBD and THC – Psychoactivity

cbd and thcDid you know that of all the substances making up Cannabis as a complete plant, only one can cause a psychoactive effect when Cannabis is taken into the body by means of consumption, inhaling or topical application?

And that substance is not Cannabidiol, but its sister Cannabinoid called Tetrahydrocannabinol (THC for short).

Another interesting fact that is not commonly known, is that alcoholic beverages, which are completely legally obtainable globally, are also psychoactive and can cause far more damage to your body (and your relationships) than Cannabis. Especially when referring to Cannabis strains that are low in THC, but high in CBD.

Recent research on the effects of various Cannabis-derived substances in the human body has positively determined that CBD has no psychoactive properties whatsoever.

Also interesting to note, is that CBD actually counteracts the psychoactive activities of THC, meaning that a strain of Cannabis that contains a percentage equal to or higher than the percentage of THC in the same strain, will have little to no psychoactive effect on the consumer.

Related Articles:

Legality of Cannabinoids

legal cannabisHowever, whatever the case may be, Cannabis is still outlawed in most parts of the world, and Medical Cannabis strains and products are globally controlled to the extent that the percentage of THC in such a product should be equal to or lower than 0.01% in order to be legal.

As mentioned earlier, research has shown that CBD and CBD containing products have no psychoactive properties whatsoever and that CBD counteracts the psychoactive effect of THC on the human body.

CBD Hemp Oil is a variety of CBD Oil that is derived from Hemp, which is a strain of Cannabis that contains virtually no THC but is rich in CBD. Because of this absence of THC in the Hemp plant, Hemp is completely legal globally, and so are the products that are manufactured from it.

The medical industry has now turned to Hemp in order to provide remedies that are effective against all of the diseases and conditions that Medical Cannabis are used for, such as migraines, anxiety, multiple sclerosis, epileptic and even cancer.

Related Article:

CBD for Insomnia

CBD for InsomniaOne such condition that can be treated with CBD, is Insomnia. In the United States alone, approximately 70 million citizens suffer from insomnia, and that figure grows significantly when the rest of the world is taken into account.

It has been determined that, in small doses, CBD can effectively treat insomnia, ensuring a good night’s rest without the alarming side effects of conventional drugs that are commonly used to treat insomnia. CBD keeps you alert when you need to be awake, and induces sleep when you need to sleep.

According to the most recent research, Cannabidiol (CBD) may be a viable option for treating people who suffer from insomnia.

Different doses of CBD was administered to groups of rats in order to compare their sleep habits, and a control group was given no CBD at all. Results were that those rats treated with CBD have shown a larger total amount of sleep time than those in the control group.

CBD was found to have an overall effect of having larger amounts of total time sleeping. It was also determined that the rats were less inclined to fall asleep during the daytime, resulting in the rats getting enough sleep during the nights, inducing a normal wake/sleep pattern.

Wakefulness at day – sleepy at night

Wakefulness at day – sleepy at nightIt has been found that administering CBD to rats during the day promoted wakefulness. Rats that were deprived of sleep during the night found it easier to stay awake during the day and, essentially, rats that received CBD under those conditions slept normally the next night and did not seem to need extra sleep (sleep rebound) that would usually be the case after a night of poor sleep. Note that humans also experience sleep rebound when they do not get enough sleep.

These exciting results suggest that CBD may have a much more intricate role in regulating sleep, and may be of higher significance in natural sleep-related patterns than potentially addictive conventional drugs that are usually prescribed by medical professionals for treating sleep disorders, and specifically insomnia.

Note, however, that these are early findings that will need to be followed by studies with humans. New findings will be reported as soon as results are available.

Trouble falling asleep at night or staying awake during the day? You may benefit from a CBD supplement, and you might find a product that will be ideal for you in our CBD Hemp Oil shop. A good night’s rest is important for a long, active and productive day. To find out more, go here.

Feel free to browse until you find what you need for treating your insomnia. Sleeping well is key to feeling healthy and energetic all day long.

Featured Products

CBD for Diabetes – Treatment for Disease and Symptoms?

CBD for Diabetes – Treatment for Disease and Symptoms?

cbd for diabetesDiabetes is the name used to refer to a cluster of metabolic disorders characterized by the prolonged presence of high glucose levels in the blood. There are about 400 million of people that are affected by diabetes worldwide, and year after year, its prevalence continues to rise. Various treatments for diabetes are available. Recently, significant evidence was found suggesting positive effects of (Cannabidiol) CBD for diabetes. Read more

Send this to a friend