In this article, we look at CBD oil for inflammation and the anti-inflammatory properties of cannabidiol. We try to simplify it too because it can be a quite a complicated process.
What is Inflammation & what happens in the body
Well let’s let’s just use an example. Inflammation can be good and it can be bad. In the normal area you have an inflammation and that enhances healing. And so that’s the real purpose of inflammation, it’s both healing and protection.
Protection in the sense that you have an area that maybe has an infection and you want to bring in those macrophages and those immune elements that are going to clean up the mess. Or if that’s damaged tissue clean that out. So that the full healing can occur.
But the process of inflammation is quite intriguing. It’s a little bit like getting a 9-1-1 call. In that you send an ambulance or a firetruck or a policeman out there. Which is you don’t really know until you sort of get there.
Purpose of Inflammation & Cytokines
So the inflammation is a signal to the body, it’s the 911. You need to go out and check that out. And so the body sends immune cells. The first step is, it invites the immune cells or the immune cells are already there.
They start to signal back to the body and they will stimulate and release these inflammatory substances in the area.
And when that happens then you have either the reaction that occurs that protects against the toxins or you have the recruitment of other immune cells.
In that process you have many of the other immune cells are coming to the area as well, as those irritating substances are called cytokines that are released into the area.
And those are the ones that cause the redness and the swelling and the heat and the pain that go on. Now, the next process should be the healing process. And that pretty well works most of the time.
But for a lot of us who are facing chronic diseases, then you can imagine that this 9-1-1 call is like a light switch, it gets turned on but somebody forgot to turn it off.
Chronic inflammation & how to calm it down
Steroids, they may work but they eventually cause further destruction and further damage and you can’t keep up with that.
The prolotherapy sounds like a great idea to involve for those chronic situations that are there. But not really, it may not be chronic inflammation or in the sense that we see in terms of destructive inflammation, that we’re typically seeing. But enough to cause significant amount of pain.
CBD Oil for Inflammation: Pain & Cytokines
First off, when there is inflammation, Cannabidiol can go in and they can alleviate at least a portion of the pain. It provides some analgesia to the area.
And then it starts interfering with the cytokines of those inflammatory substances that are causing a lot of the symptoms.
Whether it’s pain or its recruitment of the immune cells.
Or it’s the swelling and increase permeability of the vessels that are around the area. Or it’s the redness or it’s actually the amount of recruitment of the inflammatory cells that are there.
CBD Oil for Inflammation: Macrophages & the communication within the cell
Cannabidiol has actually been shown to reduce the number of those macrophages and those inflammatory cells that are populating area.
Even to the point of reducing the number of antibodies that are being presented to the T-cells for differentiation and creating antibodies to in the inflammatory process that’s going on.
So a number of fascinating responses that are going on.
On the same line, CBD is going intracellularly to affect the communication within the cell, whether it’s at the mitochondrial level or the endoplasmic reticulum or it’s at the nucleus.
A lot of that communication is actually signaled by Cannabidiol. And improves the functioning that goes on with it. And as a result you have this global possibility of improvement in a number of inflammatory situations.
CBD & Inflammatory bowels/Crohn’s disease
A really classical example, that we see is inflammatory bowel disease. So we’re talking about crohn’s disease and ulcerative colitis. Three weeks of cannabidiol we’ve seen in patients absolutely normalize their gut function.
To the point, where at six weeks they have a normal endoscopy.
So we’re talking about a severely inflamed situation in the gut. Dealing with tumor necrosis factor, this kind of cytokine. A number of the other cytokines that are circulating in the body.
CBD – Restoring balance in the Intestines
CBD has the effect of calming that all down and restoring the tight junctions that are involved in the intestines and restoring balance to the gut.
As well as reducing the motility, the typical hyper motility that’s giving people the frequent diarrhea.
So, you have this wonderful balanced effect, that’s going on with the inflammatory bowel disease.
Typically patients, who are having inflammatory bowel disease have an autoimmune disorder has been initiated. And so, something has triggered that in our perspective.
We see that as a combination of factors. Is not one thing, but these people already prone to it. So yes, we would say they need to continue the usage of CBD but not at the same dosage level.
They may be able to drop down their dosage and we reccomend only about a quarter of what we were taking for the acute problems, in order to maintain unsustained the benefits, that you’re receiving and the anti-inflammatory effect. And prevent the recurrence of the autoimmune.
What would be an initial dose or the recommendation?
So for inflammatory bowel disease, we see that as a crisis point. So to us, at that crisis point we want to use maximum therapy and want to get that under control.
A lot of people are just introduced at that point in time, so we going to recommend 90 milligrams of CBD coming typically from the tincture. Because we know that that’s highly effective.
Now after they’ve been on that for a while and they have got some decrease in the inflammation, they’ve had some improvement and we can drop it down to 60mg.
We always put things in terms of the number of milligrams of CBD and you can just calculate it from the concentration of the bottle that’s there in. For a systemic disease like crohn’s disease probably talking about twice a day but maybe three times a day.
The other thing that goes on with Cannabidiol is, it’s unique, every individual is different in terms of its effect and how you are going to respond. Or where you are deficient in your own personal cannabinoids. You have to find that by a little bit of dosing.