Cancer

This is our library on scientific research related to CBD, the Endocannabinoid System, other cannabinoids and Cancer. Below you will find a list of conditions for which there are one or more scientific studies of CBD. The source of these scientific studies relates primarily to PubMed, an online service of the U.S. National Library of Medicine.

Important: The studies that are listed by PubMed are for the most part preclinical research. These relate in most cases to animal experiments with isolated CBD (pure CBD) and not fully extracted CBD extract. Although mammals have cell receptors that respond to cannabinoid compounds, the data collected from animal studies are not always 1: 1 applicable to humans. Always check with your physician before starting a new dietary supplement program. Learn more at: The Basics of CBD Oils and Cannabis as a Therapeutic Agent

Antitumorigenic targets of cannabinoids – current status and implications
Cannabinoids – a new weapon against cancer?
CBD as potential anticancer drug
CBD inhibits angiogenesis by multiple mechanisms
CBD inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
CBD, a novel inverse agonist for GPR12
In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
Marijuana fights cancer and helps manage side effects
The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion
The inhibitory effects of CBD on systemic malignant tumors

Breast

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
CBD as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
CBD induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
CBD-A mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells
Pathways mediating the effects of CBD on the reduction of breast cancer cell proliferation, invasion, and metastasis

Bladder

TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Brain

Antitumor effects of CBD, a nonpsychoactive cannabinoid, on human glioma cell lines
Cannabidiol enhances the inhibitory effects of delta9-THC on human glioblastoma cell proliferation and survival
Cannabis improved survival of patients with aggressive brain cancer in controlled clinical study
CBD inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
CBD inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
Synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture
Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

Colon

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of CBD

Endocrine

A comparative study on CBD-induced apoptosis in murine thymocytes and EL-4 thymoma cells
Endocannabinoids in endocrine and related tumours  

Kaposi Sarcoma

CBD inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium

Lung

CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of CBD on human lung cancer cells
Media ignored expert’s shocking findings that marijuana helps prevent lung cancer

Leukemia

Cannabidiol Reduces Leukemic Cell Size – But Is It Important?  
CBD-Induced Apoptosis in Human Leukemia Cells  
CBD-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression  

Prostate

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines
Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
owards the use of non-psychoactive cannabinoids for prostate cancer

Pain

Marijuana extract helps prevent chemo pain
Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial  

Skin

Anticancer activity of anandamide in human cutaneous melanoma cells

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