Digestive issues

This is our library on scientific research related to CBD, the Endocannabinoid System, other cannabinoids and Digestive issues. Below you will find a list of conditions for which there are one or more scientific studies of CBD. The source of these scientific studies relates primarily to PubMed, an online service of the U.S. National Library of Medicine.

Important: The studies that are listed by PubMed are for the most part preclinical research. These relate in most cases to animal experiments with isolated CBD (pure CBD) and not fully extracted CBD extract. Although mammals have cell receptors that respond to cannabinoid compounds, the data collected from animal studies are not always 1: 1 applicable to humans. Always check with your physician before starting a new dietary supplement program. Learn more at: The Basics of CBD Oils and Cannabis as a Therapeutic Agent

Irritable Bowel Syndrome

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)
Cannabidiol in inflammatory bowel diseases: A brief overview 
Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation
CBD and gastrointestinal motility 
CBD and the gut: New developments and emerging concepts
CBD reduces intestinal inflammation through the control of neuroimmune axis
Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
Endocannabinoids and the gastrointestinal tract
Getting into the weed: the role of the endocannabinoid system in the brain-gut axis
Therapeutic potential of cannabinoid-based drugs

Colitis and Crohn’s

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
Cannabinoids and gastrointestinal motility: Animal and human studies
Cannabinoids and the gut: New developments and emerging concepts
Cannabis finds its way into treatment of Crohn’s disease
CBD in inflammatory bowel diseases: a brief overview
CBD reduces intestinal inflammation through the control of neuroimmune axis
Endocannabinoids and the gastrointestinal tract
Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis
Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial.
Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review
The effects of Delta-tetrahydrocannabinol and CBD alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice

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